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AZM475271 (M475271)
An inhibitor of c-Src kinase
Gilteritinib hemifumarate
A FLT3 inhibitor
FLT3-IN-4
FLT3-IN-4 是一种口服有效的 Fms 样酪氨酸受体激酶 3 (FLT3; IC50= 7 nM) 抑制剂,可用于治疗急性髓性白血病。
Gilteritinib
FLT3-IN-2
An inhibitor of FLT3, c-Kit, and c-FMS
FLT3 Inhibitor III
A potent, highly selective inhibitor of FLT3
MRX-2843 (UNC2371)
A Mer and FLT3 inhibitor
BPR1J-097
An FLT3 inhibitor
FLT3-IN-1
FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.
UNC2541
UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK) that binds in the MerTK ATP pocket with IC50 of 4.4 nM. UNC2541 inhibits phosphorylated MerTK (pMerTK) with EC50 of 510 nM.
FLT3-IN-1 Succinate
FLT3-IN-1Succinate是有效地FLT3抑制剂,来自专利WO2015056683A1,化合物实例A。
TAK-659
TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
UNC2025
An orally bioavailable inhibitor of Mer and Flt3
G-749
An FLT3 kinase inhibitor
SKLB4771 (FLT3-IN-1)
SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10?nM.