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- Acetyl-CoA carboxylase (ACC)
- DL-threo-2-methylisocitrate sodium
DL-threo-2-methylisocitrate sodium
DL-threo-2-methylisocitrate 是异柠檬酸裂解酶 1(ICL1) 的底物。
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包装价格促销价数量
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1000mg￥75500.0060400.00- +
- 货号: ajcx11396
- CAS: N/A
- 别名:
- 分子式: C14H14Na6O14
- 分子量: 544.19
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
DL-threo-2-methylisocitrate sodium is a substrate of isocitratelyase 1(ICL1).
ICL1 had dual activity for both threo-D(s)L(s)-isocitrate (ICA) and DL-threo-2-methylisocitrate (MICA). Using Michaelis-Menten non-linear least squares fit, the Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 mM with akcatof 5.24 s-1 .The Km of ICL2 for MICA was greater than 15 mM which was too high to be determained accurately due to the limitations of the solubility of MICA. The Kcat/Km for ICL1, a measureforcatalyticefficiency, was 2.79 × 104 M-1 s-1 and 1.74 ×103 M-1 s-1, for ICA and MICA respectively.
Reference:
[1].? Gould TA1,van de Langemheen H,Muoz-Elías EJ,McKinney JD,Sacchettini JC. Dual role of isocitratelyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.Mol Microbiol.2006 Aug;61(4):940-7.
