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  • EIDD-2801
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EIDD-2801

A prodrug form of EIDD-1931

原价
¥737-4900
价格
590-3920
EIDD-2801的二维码

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  • 库存: 现货
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  • 货号: ajcx11522
  • CAS: 2349386-89-4
  • 别名: EIDD2801,EIDD 2801
  • 分子式: C??H??N?O?
  • 分子量: 329.31
  • 纯度: >98%
  • 溶解度: 100 mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

EIDD-2801 is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-2801 has the potential for COVID-19, and seasonal and pandemic influenza treatment.


Reference:
[1]. Sheahan TP, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6. pii: eabb5883.
[2]. Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515). pii: eaax5866.

Protocol

EIDD-2801 (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease[1].
EIDD-2801 (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever[2].


Animal Model: C57BL/6 mice (intranasal infection with SARS-CoV)[1]
Dosage: 50, 150, 500 mg/kg
Administration: Oral; every 12 hours for 3 days
Result: Body weight loss is significantly diminished or prevented.
Animal Model: Ca/09-infected female ferrets[1]
Dosage: 7 mg/kg
Administration: Oral; twice daily for 3.5 days
Result: Shed virus load and duration of fever were significantly reduced.

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