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  • (Rac)-Benpyrine
(Rac)-Benpyrine的可视化放大

(Rac)-Benpyrine

An inhibitor of the TNF-α-TNFR1 protein-protein interaction

原价
¥1812-5400
价格
1450-4320
(Rac)-Benpyrine的二维码

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  • 库存: 现货
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  • 货号: ajcx11566
  • CAS: 1333714-43-4
  • 别名:
  • 分子式: C??H??N?O
  • 分子量: 308.34
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: 4°C, protect from light
  • 库存: 现货

Background

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].


(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].


(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].
Reference:


[1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.

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