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  • CTPI-2
CTPI-2的可视化放大

CTPI-2

A mitochondrial citrate transporter inhibitor

原价
￥675-1262
价格
￥ 540-1010
CTPI-2的二维码

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  • 库存: 现货
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  • 货号: ajcx11594
  • CAS: 68003-38-3
  • 别名: 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
  • 分子式: C13H9CIN2O6S
  • 分子量: 356.74
  • 纯度: >98%
  • 溶解度: DMSO:125 mg/mL(350.40 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and sphere-forming capacity of the indicated tumor cells relative to monolayer cultures, demonstrates broad activity on lung CSCs, inhibiting mitochondrial respiratory activity, self-renewal and matrix invasion; inhibits tumor growth in in vivo models of NSCLC.


Reference:
[1]. Fernandez HR, et al. Cell Death Differ. 2018 Jul;25(7):1239-1258.

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