GSK2807 Trifluoroacetate
GSK2807 Trifluoroacetate 是一种有效的、选择性的、SAM 竞争性的 SMYD3 抑制剂，Ki 为 14 nM，IC50 为 130 nM。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥2312.001850.00- +
-
10mg￥3600.002880.00- +
-
25mg￥7200.005760.00- +
-
50mg￥11450.009160.00- +
-
100mg￥17012.0013610.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajcx11600
- CAS: 2245255-66-5
- 别名:
- 分子式: C21H33F3N8O7
- 分子量: 566.53
- 纯度: ＞98%
- 溶解度: Water : ≥ 50 mg/mL (88.26 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM.
A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively)[1].
参考文献:
[1]. Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.
