SRI-011381 hydrochloride

A TGF-β signaling activator

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库存: 现货

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1mg

￥275.00

220.00

- +
5mg

￥612.00

490.00

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10mg

￥1087.00

870.00

- +
25mg

￥2250.00

1800.00

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50mg

￥3625.00

2900.00

- +
100mg

￥5812.00

4650.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

SRI-011381 hydrochloride is a TGF-beta signaling agonist.target: TGF-betaIn vitro: SRI-11381 is neuroprotective. SRI-011381 promot fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.In vivo: SRI-011381 is a biologically active inducer of TGF-β signaling in cell culture and in vivo. SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (ip.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

Reference:
[1]. Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb
[2]. Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.