ML-SI1

ML-SI1 是一种非对映异构体的外消旋混合物，是一种 TRPML 抑制剂，对 TRPML1 的 IC50 值为 15 μM。

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库存: 现货

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5mg

￥3975.00

3180.00

- +
10mg

￥6600.00

5280.00

- +
25mg

￥12400.00

9920.00

- +
50mg

￥19175.00

15340.00

- +
100mg

￥28200.00

22560.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1.

ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments confirmed that the synthesized racemic ML-SI1 (10 μM) has an inhibitory effect on hTRPML1[1].

Reference:
[1]. Charlotte Leser, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.