Taurodeoxycholic Acid-d4 (sodium salt)

An internal standard for the quantification of taurodeoxycholic acid

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1mg

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货号: ajcx12058
CAS: 2410279-82-0
别名: Sodium Taurodeoxycholate-d4; TDCA-d4
分子式: C26H40D4NO6S ? Na
分子量: 525.7
纯度: >98%
溶解度: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid [1] Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.[2] Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.[1]

Reference:
[1]. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).
[2]. Hendrick, S.M., Mroz, M.S., Greene, C.M., et al. Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 307(5), L407-L418 (2014).