An internal standard for the quantification of taurodeoxycholic acid
Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid [1] Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.[2] Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.[1]
Reference:
[1]. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).
[2]. Hendrick, S.M., Mroz, M.S., Greene, C.M., et al. Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 307(5), L407-L418 (2014).
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