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- Broflanilide
Broflanilide
Broflanilide是一种杀虫剂，可以分解成desmethyl-broflanilide，为特异性的昆虫耐狄氏剂的GABAreceptor拮抗剂，抑制斜纹夜蛾RDLGABAR，IC50值为1.3nM。
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包装价格促销价数量
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5mg￥1300.001040.00- +
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10mg￥2175.001740.00- +
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50mg￥8450.006760.00- +
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100mg￥13500.0010800.00- +
- 货号: ajcx12398
- CAS: 1207727-04-5
- 别名: 氟苯双酰胺
- 分子式: C25H14BrF11N2O2
- 分子量: 663.28
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.
Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM)[1].
[1]. Nakao T, et al. Broflanilide: A meta-diamide insecticide with a novel mode of action. Bioorg Med Chem. 2016 Feb 1;24(3):372-7.
