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- HDAC (Histone deacetylases)
- ACY-957
ACY-957
ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。
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包装价格促销价数量
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5mg￥3375.002700.00- +
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10mg￥5500.004400.00- +
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25mg￥11875.009500.00- +
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50mg￥17100.0013680.00- +
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100mg￥23512.0018810.00- +
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- 货号: ajcx12400
- CAS: 1609389-52-7
- 别名:
- 分子式: C24H23N5OS
- 分子量: 429.54
- 纯度: ＞98%
- 溶解度: DMSO : 83.33 mg/mL (194.00 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1].
[1]. Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.
