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- Angiotensin-converting Enzyme (ACE)
- SIRT-IN-1
SIRT-IN-1
SIRT-IN-1是SIRT1/2/3的有效抑制剂，其IC50值分别为15，10，33μM。
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250mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx12456
- CAS: 1431411-60-7
- 别名:
- 分子式: C19H27N5O2S
- 分子量: 389.52
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.
