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CGRPantagonist1是高效的CGRP受体拮抗剂,Ki和IC50值分别为35和57nM。
CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.
CGRP antagonist 1 is compound 20[1].
[1]. Stump CA, et al. The discovery of highly potent CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Jan 1;19(1):214-7.
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