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FR-190809是一种有效、可口服、无肾上腺毒性的酰基辅酶A-胆固醇酰基转移酶(ACAT)抑制剂,IC50值为45nM。
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].
FR-190809 inhibits foam cell formation with an IC50 of 215 nM[1].
[1]. Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41(22):4408-20.
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