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Elobixibat (A 3309) 是一种有效的回肠胆汁酸转运蛋白 (IBAT) 抑制剂,IC50 值为 0.53 ±; 0.17纳米,0.13 ±; 0.03 nM,和 5.8 ±;人类 IBAT、小鼠 IBAT 和犬 IBAT 为 1.6 nM。
Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
[1]. Wong BS, et al. Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb; 22(2):277-84.
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