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- Acetylcholinesterase (AChE or acetylhydrolase)
- SNT-207707
SNT-207707
SNT-207707是一种有效，选择性，有口服活性的黑素皮质素受体(melanocortinMC-4)拮抗剂，IC50值为8nM(结合)和5nM(功能)。
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包装价格促销价数量
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250mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx12620
- CAS: 1064662-40-3
- 别名:
- 分子式: C32H44ClN5O
- 分子量: 550.18
- 纯度: ＞98%
- 溶解度: DMSO: ≥ 250 mg/mL (454.40 mM); Methanol: 250 mg/mL (454.40 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.
SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1].
Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].
[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.
Protocol
Animal experiment: | Mice[1]Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60 mg/kg (n=9 per compound). At 1, 3, and 6 hrs post-dose, 3 mice from each compound group are euthanized with CO2. Blood is collected by cardiac puncture, plasma is isolated immediately and then kept on dry ice until analysis[1]. |
参考文献: [1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. | |
