GW 766994 (GW 994)
An antagonist of CCR3
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥3987.003190.00- +
-
10mg￥6362.005090.00- +
-
25mg￥12600.0010080.00- +
-
50mg￥18487.0014790.00- +
-
100mg￥27737.0022190.00- +
- 货号: ajcx12726
- CAS: 408303-43-5
- 别名: GW 994
- 分子式: C21H24Cl2N4O3
- 分子量: 451.35
- 纯度: ＞98%
- 溶解度: DMSO : 56 mg/mL (124.07 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11).1 It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid β (1-42) (Aβ42) in isolated mouse hippocampal neurons when used at a concentration of 10 ?M.2
1.Neighbour, H., Boulet, L.-P., Lemiere, C., et al.Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: A randomized, placebo-controlled clinical trialClin. Exp. Allergy44(4)508-516(2014) 2.Zhu, C., Xu, B., Sun, X., et al.Targeting CCR3 to reduce amyloid-β production, tau hyperphosphorylation, and synaptic loss in a mouse model of Alzheimer's diseaseMol. Neurobiol.54(10)7964-7978(2017)
