MIV-150 (PC 815)
A non-nucleoside reverse transcriptase inhibitor
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包装价格促销价数量
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250mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx12794
- CAS: 231957-54-3
- 别名: PC 815
- 分子式: C19H17FN4O3
- 分子量: 368.36
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL,Ethanol: 0.25 mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro).1 It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors.1 Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.2,3
1.Fernández-Romero, J.A., Thorn, M., Turville, S.G., et al.Carrageenan/MIV-150 (PC-815), a combination microbicideSex. Transm. Dis.34(1)9-14(2007) 2.Turville, S.G., Aravantinou, M., Miller, T., et al.Efficacy of Carraguardr-based microbicides in vivo despite variable in vitro activityPLoS One3(9)e3162(2008) 3.Singer, R., Derby, N., Rodriguez, A., et al.The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaquesJ. Virol.85(11)5504-5512(2011)
