OT antagonist 1
OTantagonist1(Compound4)是一种有效的选择性催产素(Oxytocin)拮抗剂，Ki为50nM。
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包装价格促销价数量
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250mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx12810
- CAS: 479080-38-1
- 别名:
- 分子式: C22H22N4O3
- 分子量: 390.44
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists[1].
[1]. Brown A, et al. Design and optimization of potent, selective antagonists of Oxytocin. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4278-81.
