AZD2906为一种选择性的糖皮质激素受体glucocorticoidreceptor(GR)激动剂，对人、大鼠PBMC和全血中GR的IC50值分别为2.2，0.3，41.6和7.5nM。AZD2906能够增加大鼠骨髓中的微核未成熟红细胞。
AZD2906 is a selective glucocorticoid receptor (GR) agonist, with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively. AZD2906 increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats[1].
AZD2906 is a selective glucocorticoid receptor (GR), with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1].
AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days[1].AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats, and exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats[1].|| Animal Model:|Male Wistar Han rats (10 weeks old)[1]|Dosage:|5, 25, 50 mg/kg|Administration:|P.O. for 2 days|Result:|Caused significant increases in micronucleated immature erythrocytes (MIE) at all doses after analysis of the standard 2000 IE.
[1]. Hayes JE, et al. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. I: glucocorticoid receptor agonism. Mutagenesis. 2013 Mar;28(2):227-32.
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