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- CE-245677
CE-245677
CE-245677是一种有效的，可逆的Tie2和TrkA/B抑制剂，在细胞体系下，IC50值分别为4.7和1nM。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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250mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx12842
- CAS: 717899-97-3
- 别名:
- 分子式: C24H22Cl2N6O3
- 分子量: 513.38
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (243.48 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].
[1]. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.
