- 首页
- Reactive oxygen species (ROS)
- Almokalant (H 234/09)
Almokalant (H 234/09)
Almokalant (H 234/09) 是一种 III 类抗心律失常药物，作为钾通道阻滞剂，可抑制时间依赖性延迟整流器 K+ 电流的特定成分 (Ikr)。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
250mg￥0.000.00- +
-
500mg￥0.000.00- +
- 货号: ajcx12854
- CAS: 123955-10-2
- 别名: 阿莫兰特,H 234?/09
- 分子式: C18H28N2O3S
- 分子量: 352.49
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current[1].
Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1].
[1]. Wellfelt K, et al. Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species. Reprod Toxicol. 1999 Mar-Apr;13(2):93-101.
