Belvarafenib
An inhibitor of B-RAF and C-RAF
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250mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx12860
- CAS: 1446113-23-0
- 别名: HM95573; GDC-5573; RG6185
- 分子式: C23H16ClFN6OS
- 分子量: 478.93
- 纯度: ＞98%
- 溶解度: DMSO: 12.5 mg/mL (26.10 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively).1 It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s = 116, 65, 43, and 479 nM, respectively). Belvarafenib reduces tumor growth in A375, SK-MEL-28, SK-MEL-2, and SK-MEL-30 mouse xenograft models.
1.Man, R.-J., Zhang, Y.-L., Jiang, A.-Q., et al.A patent review of RAF kinase inhibitors (2010-2018)Expert Opin. Ther. Pat.29(9)675-688(2019)
