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- Janus kinase (JAK)
- Gusacitinib (ASN-002)
Gusacitinib (ASN-002)
A dual inhibitor of JAKs and Syk family kinases
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包装价格促销价数量
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5mg￥850.00680.00- +
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10mg￥1300.001040.00- +
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50mg￥4850.003880.00- +
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- 货号: ajcx12870
- CAS: 1425381-60-7
- 别名: ASN-002
- 分子式: C24H28N8O2
- 分子量: 460.53
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (217.14 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Gusacitinib is a dual inhibitor of JAKs (IC50s = 46, 4, and 11 nM for JAK1-3, respectively) and Syk family kinases (IC50s = 5 and 8 nM for SyK and TYK2, respectively).1
1.Bissonnette, R., Maari, C., Forman, S., et al.The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: Results from a randomized double-blind placebo-controlled studyBr. J. Dermatol.181(4)733-742(2019)
