RMC-4550
A SHP-2 inhibitor
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包装价格促销价数量
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5mg￥2937.002350.00- +
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10mg￥4425.003540.00- +
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50mg￥11875.009500.00- +
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100mg￥17775.0014220.00- +
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- 货号: ajcx12872
- CAS: 2172651-73-7
- 别名:
- 分子式: C21H26Cl2N4O2
- 分子量: 437.36
- 纯度: ＞98%
- 溶解度: DMSO : 125 mg/mL (285.81 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
RMC-4550 is an inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2; IC50 = 1.55 nM).1 It is selective for SHP-2 over a panel of 14 additional protein phosphatases and a panel of 468 protein kinases at 10 ?M. It inhibits tumor ERK phosphorylation in a KYSE-520 human esophageal cancer xenograft model in a dose-dependent manner.
1.Koltun, E.S., Aay, N., Buckl, A., et al.RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activityCancer Res.78(13 Suppl.)(2018)
