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JAK1-IN-4是一种有效、选择性的JAK1抑制剂,对JAK1,JAK2和JAK3的IC50值分别为85nM,12.8μM和>30μM。在NCI-H1975细胞中,JAK1-IN-4抑制STAT3的磷酸化,IC50值为227nM。
JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].
[1]. Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak.
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