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  • A1874
A1874的可视化放大

A1874

A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.

原价
￥6275-18637
价格
￥ 5020-14910
A1874的二维码

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  • 库存: 现货
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  • 货号: ajcx12960
  • CAS: 2064292-12-0
  • 别名:
  • 分子式: C58H62Cl3F2N9O7S
  • 分子量: 1173.59
  • 纯度: >98%
  • 溶解度: DMSO : 150 mg/mL (127.81 mM);Water : < 0.1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.


In HCT116 cells, A1874 causes a 97% decrease in viability and in A375 cells, A1874 causes a 98% loss of viability.A1874 reduced viability of Daudi cells by 70% and of MOLM-13 cells by 95%.[1]


[1] Hines J,et al.Cancer Res.2019,1;79(1):251-262.

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