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- HSP (Heat shock proteins)
- TAS-116
TAS-116
An Hsp90 inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥287.00230.00- +
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5mg￥637.00510.00- +
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10mg￥1212.00970.00- +
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50mg￥4025.003220.00- +
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100mg￥6562.005250.00- +
- 货号: ajcx12966
- CAS: 1260533-36-5
- 别名: TAS-116
- 分子式: C25H26N8O
- 分子量: 454.53
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (275.01 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
TAS 116 is a heat shock protein 90 (Hsp90) inhibitor.1 It selectively binds to Hsp90α and Hsp90β (Kis = 34.7 and 21.3 nM, respectively) over glucose-regulated protein 94 (GRP94) and TGF-β receptor-associated protein 1 (TRAP1; Kis = 50,000 nM for both). TAS 116 (3.6, 7.1, and 14 mg/kg) reduces intratumoral protein levels of HER2, HER3, and Akt, as well as reduces tumor growth in a HER2-expressing NCI N87 gastric cancer mouse xenograft model and does not induce photoreceptor injury in rats when administered at a dose of 12 mg/kg per day.
1.Ohkubo, S., Kodama, Y., Muraoka, H., et al.TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical modelsMol. Cancer Ther.14(1)14-22(2015)
