2-Keto Crizotinib (PF-06260182)
2-Keto Crizotinib (PF-06260182) (PF-06260182) 是 crizotinib 的活性内酰胺代谢物。
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250mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx12988
- CAS: 1415558-82-5
- 别名: 克里唑替尼杂质,PF-06260182
- 分子式: C21H20Cl2FN5O2
- 分子量: 464.32
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.
[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.
