CMPD 7
CMPD 7 是一种有效的选择性 CDK12 抑制剂，在酶促试验中的 IC50 为 491 nM。
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250mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx12996
- CAS: 2220184-50-7
- 别名:
- 分子式: C23H28F2N8O
- 分子量: 470.52
- 纯度: ＞98%
- 溶解度: DMSO: 250 mg/mL (531.33 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.
CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].
[1]. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.
