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  • CMPD 7
CMPD 7的可视化放大

CMPD 7

CMPD 7 是一种有效的选择性 CDK12 抑制剂，在酶促试验中的 IC50 为 491 nM。

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  • 库存: 现货
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  • 货号: ajcx12996
  • CAS: 2220184-50-7
  • 别名:
  • 分子式: C23H28F2N8O
  • 分子量: 470.52
  • 纯度: >98%
  • 溶解度: DMSO: 250 mg/mL (531.33 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.


CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].


[1]. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.

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