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- Antifolate
- LY 222306
LY 222306
LY222306是甘氨酰胺核糖核苷酸甲酰转移酶((GARFT))的抑制剂，Ki值为0.77nM。
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- 货号: ajcx13036
- CAS: 154446-98-7
- 别名:
- 分子式: C19H23N5O7
- 分子量: 433.42
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
[1]. Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6.
