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KRASG12Cinhibitor5是一种KRasG12C抑制剂,详细信息请参考专利文献WO2017201161A1中的化合物147。
KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1].
Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation[1].
[1]. John P. Fischer, et al. Kras g12c inhibitors. WO2017201161A1.
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