Cecropin A TFA
CecropinATFA是由37个氨基酸残基构成的线性抗菌肽，从Hyalaphoracecropiapupae得到，具有抗菌、抗炎和抗癌作用。
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包装价格促销价数量
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1mg￥2037.001630.00- +
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5mg￥5237.004190.00- +
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10mg￥7912.006330.00- +
- 货号: ajcx13194
- CAS: N/A
- 别名: 抗菌肽三氟醋酸盐
- 分子式: C186H314N53O48F3
- 分子量: 4117.8
- 纯度: ＞98%
- 溶解度: Water : ≥ 50 mg/mL (12.14 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory[1] and anti-cancer activity[2].
Cecropin A (10, 20, 30, 40 and 50 μM) induces cytotoxicity on HL-60 cells in a dose-dependent manner. Cecropin A induces apoptosis independent of caspase activation[1].Cecropin A shows good antibacterial activity against both multidrug-resistant Gram-negative bacteria such as A. baumanii (MDRAB) and multidrug-resistant P. aeruginosa (MDRPA) with IC50s of 0.5-1 μM.Cecropin A (0.1, 0.25 μM) exhibits anti-inflammatory activities. Cecropin A (25 μM) effectively suppresses the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibits the expression of mMIP-1 mRNA. Cecropin A also effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduced the expression of COX-2[2].
[1]. Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503. [2]. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.
