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ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1].
[1] Martin K, et al. iScience. 2018, 8:74-84.
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