A ZIP7 inhibitor
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).1 It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 ?M) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin in MDA-MB-231 and RCC4 cells when used at a concentration of 10 ?M.2
1.Nolin, E., Gans, S., Llamas, L., et al.Discovery of a ZIP7 inhibitor from a Notch pathway screenNat. Chem. Biol.15(2)179-188(2019) 2.Chen, P.-H., Wu, J., Xu, Y., et al.Zinc transporter ZIP7 is a novel determinant of ferroptosisCell Death Dis.12(2)198(2021)
动态评分
0.0