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  2. Angiotensin-converting Enzyme (ACE)
  3. 6H05 trifluoroacetate (K-Ras inhibitor)
  • 6H05 trifluoroacetate (K-Ras inhibitor)
6H05 trifluoroacetate (K-Ras inhibitor)的可视化放大

6H05 trifluoroacetate (K-Ras inhibitor)

6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).

原价
￥1000-2637
价格
￥ 800-2110
6H05 trifluoroacetate (K-Ras inhibitor)的二维码

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  • 库存: 现货
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  • 货号: ajcx13554
  • CAS: N/A
  • 别名:
  • 分子式: C22H31ClF3N3O4S3
  • 分子量: 590.14
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 51 mg/mL (86.42 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).


6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras. [1]. Furthermore, 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors. [2]


[1] Ostrem JM, et al. Nature. 2013, 503(7477), 548-551. [2] Lu S, et al. Med Res Rev. 2014, 34(6), 1242-1285.

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