CCR6inhibitor1是一种有效、选择性的CCR6抑制剂，对猴子和人CCR6的IC50值分别为0.45和6nM，对其选择性远高于人CCR1(IC50，>30000nM)和CCR7(IC50，9400nM)。CCR6inhibitor1显著抑制ERK磷酸化。可用于自身免疫病和癌症的研究。
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Moneky CCR6|0.45 nM (IC50)|Human CCR6|6 nM (IC50)|Human CCR7|9400 nM (IC50)
CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1].
[1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.
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