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PROTACRARDegrader-1包含cIAP1配体结合基团,linker和RAR配体结合基团。在HT1080细胞中,PROTACRARDegrader-1降低RAR水平,30μM浓度时达到最大降解程度。同时,基于cIAP1的降解剂也被称为SNIPER。
PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
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