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- RIP kinase
- A 83-01 sodium salt
A 83-01 sodium salt
A TGF-β type I receptor inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥371.00260.00无库存
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5mg￥571.00400.00- +
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10mg￥857.00600.00- +
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50mg￥2571.001800.00- +
- 货号: ajcx13680
- CAS: 2828431-89-4
- 别名: 3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide, sodium salt
- 分子式: C25H19N5NaS
- 分子量: 443.5
- 纯度: ＞98%
- 溶解度: DMSO: 100 mg/mL (224.97 mM); Water: < 0.1 mg/mL (insoluble)
- 储存: 4°C, protect from light *Product is unstable in the solution state, it is recommended that you use it now and use it immediately
- 库存: 现货
Background
A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively).1 It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition.1 It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK.1 A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes.2,3
1.Tojo, M., Hamashima, Y., Hanyu, A., et al.The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-βCancer Sci.96(11)791-800(2005) 2.Cao, N., Huang, Y., Zheng, J., et al.Conversion of human fibroblasts into functional cardiomyocytes by small moleculesScience352(6290)1216-1220(2016) 3.Zhang, M., Lin, Y.H., Sun, Y.J., et al.Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activationCell Stem Cell18(5)653-667(2016)
