BPR1J-097 Hydrochloride
An FLT3 inhibitor
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包装价格促销价数量
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2mg￥550.00440.00- +
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5mg￥762.00610.00- +
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10mg￥1300.001040.00- +
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50mg￥4850.003880.00- +
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100mg￥7012.005610.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx13766
- CAS: N/A
- 别名:
- 分子式: C27H29ClN6O3S
- 分子量: 553.08
- 纯度: ＞98%
- 溶解度: DMSO: 6 mg/mL (10.85 mM and warming); Water: 2 mg/mL (3.62 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
BPR1J-097 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; IC50 = 11 nM).1 It is selective for FLT3 over FLT1, KDR, Aurora A, and Aurora B kinases (IC50s = 211, 129, 340, and 876 nM, respectively). BPR1J-097 inhibits FLT3 activity and phosphorylation of STAT5 in MV4-11 acute myeloid leukemia (AML) cells containing the FLT3 activating mutant FLT3-ITD (IC50s = 10 and 1 nM, respectively). It inhibits the growth of FLT3-dependent MOLM-13 and MV4-11 AML cells (GI50s = 21 and 46 nM, respectively) but not FLT3-/- U937 and K562 cells (GI50s = >20,000 nM for both). BPR1J-097 (25 mg/kg) inhibits tumor growth in a MOLM-13 mouse xenograft model.
1.Lin, W.-H., Jiaang, W.-T., Chen, C.-W., et al.BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AMLBr. J. Cancer106(3)475-481(2012)
