CEP-28122 mesylate salt

An orally active ALK inhibitor

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库存: 现货

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5mg

￥1625.00

1300.00

- +
10mg

￥2612.00

2090.00

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50mg

￥5937.00

4750.00

- +
100mg

￥10800.00

8640.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

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Background

CEP-28122 is a potent inhibitor of anaplastic lymphoma kinase (ALK; IC₅₀ = 1.9 nM) that less potently inhibits other tyrosine and serine/threonine kinases.¹ It blocks the phosphorylation of ALK and other ALK substrates in cells and induces concentration-dependent growth inhibition or cytotoxicity of ALK-positive cancer cells.¹ CEP-28122 is orally active, inhibiting ALK tyrosine phosphorylation in tumor xenografts in mice for more than 12 hours following single oral dosing at 30 mg/kg.¹

1.Chang, M., Quail, M.R., Gingrich, D.E., et al.CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancersMol. Cancer Ther.11(3)670-679(2012)