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- PKD (Protein kinase D)
- CTX-0294885 hydrochloride
CTX-0294885 hydrochloride
A broad spectrum kinase inhibitor used in proteomics
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥987.00790.00- +
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50mg￥4850.003880.00- +
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100mg￥7012.005610.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx13814
- CAS: N/A
- 别名:
- 分子式: C22H25Cl2N7O
- 分子量: 474.39
- 纯度: ＞98%
- 溶解度: Water: ≥ 370 mg/mL (779.95 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.1 In an affinity purification experiment, CTX-0294885 beads bound to kinases from every major group and captured all members of the AKT family of proteins. In a large-scale kinome profiling experiment, it captured 235 kinases from MDA-MB-231 breast cancer cells.
1.Zhang, L., Holmes, I.P., Hochgr?fe, F., et al.Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profilingJ. Proteome Res.12(7)3104-3116(2013)
