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  • DDD107498 succinate
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DDD107498 succinate

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

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DDD107498 succinate的二维码
  • 库存: 现货
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  • 包装
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    促销价
    数量
  • 5mg
    ￥2287.00
    1830.00
    - +
  • 10mg
    ￥3600.00
    2880.00
    - +
  • 50mg
    ￥11400.00
    9120.00
    - +
  • 100mg
    ￥16987.00
    13590.00
    - +
  • 200mg
    ￥0.00
    0.00
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  • 500mg
    ￥0.00
    0.00
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已选 0 种 0 瓶
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使用我司产品发表的文章

  • 货号: ajcx13844
  • CAS: 2444781-71-7
  • 别名: DDD107498 succinate; DDD-498 succinate; M5717 succinate
  • 分子式: C31H37FN4O6
  • 分子量: 580.65
  • 纯度: >98%
  • 溶解度: DMSO: 135 mg/mL (232.50 mM)
  • 储存: 4°C, away from moisture and light
  • 库存: 现货

Background

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.


DDD107498 shows excellent activity against 3D7 parasites, with no toxic to human cells (MRC5 and Hep-G2 cells) at much higher concentrations.[1]


There is a lag of about 24-48 h, during which time the effects of DDD107498 are reversible following wash-out. Rapid killing occurred after parasites when exposed to DDD107498 for more than 48 h.[1]


[1] Beatriz Baraga?a, et al. Nature. 2015 Jun 18;522(7556):315-20.

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