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E3 ligase Ligand-Linker Conjugates 30 TFA 包含用于 E3 泛素连接酶 cereblon (CRBN) 配体和 linker。E3 ligase Ligand-Linker Conjugates 30 TFA 可通过 PROTAC 技术合成降解剂。
E3 ligase Ligand-Linker Conjugates 30 TFA incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 TFA can be used to design PROTAC degrader[1]. Cereblon
[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.
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