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  • FC131 TFA
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FC131 TFA

An inhibitor of CXCR4 activation

原价
¥2725-8100
价格
2180-6480
FC131 TFA的二维码

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  • 货号: ajcx13900
  • CAS: N/A
  • 别名:
  • 分子式: C38H48F3N11O8
  • 分子量: 843.85
  • 纯度: >98%
  • 溶解度: DMSO: 250 mg/mL (296.26 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.1,2,3 FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM).3 FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.4


1.Broxmeyer, H.E., Orschell, C.M., Clapp, D.W., et al.Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonistJ. Exp. Med.201(8)1307-1318(2005) 2.Dorsam, R.T., and Gutkind, J.S.G-protein-coupled receptors and cancerNat. Rev. Cancer7(2)79-94(2007) 3.Tamamura, H., Hiramatsu, K., Ueda, S., et al.Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131J. Med. Chem.48(2)380-391(2005) 4.Kuil, J., Buckle, T., and van Leeuwen, F.W.B.Imaging agents for the chemokine receptor 4 (CXCR4)Chem. Soc. Rev.41(15)5239-5261(2012)

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