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A selective TRPC4 channel blocker
ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively).1 It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.1
1.Michishita, E., McCord, R.A., Berber, E., et al.SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinNature452492-496(2008)
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