现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • MS31
MS31的可视化放大

MS31

MS31 是一种细胞渗透性,高亲和性,高选择性,片段样的甲基赖氨酸读写蛋白 spindlin 1 (SPIN1) 抑制剂,有效破坏 SPIN1 与 H3K4me3 蛋白互相作用 (IC50=77 nM,AlphaLISA;243 nM,FP). MS31 选择性结合 SPIN1 的 Tudor 结构域 II (Kd=91 nM)。MS31 能有效抑制含三甲基赖氨酸肽与 SPIN1 的结合,对非肿瘤性细胞无毒。

价格
0-19230
MS31的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx14012
  • CAS: 2366264-12-0
  • 别名:
  • 分子式: C20H27N3O2
  • 分子量: 341.45
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

MS31 is a potent, cell permeable, highly affinity, and highly selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor, which potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). It selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1]. IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]Kd: 91 nM (SPIN1)[1]


MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1].


[1]. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服