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- NP-12 (TFA)
NP-12 (TFA)
NP-12 (TFA) 是 PD-1 信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。NP-12 (TFA) 具有免疫激活作用、良好的抗肿瘤活性，具有治疗免疫相关不良事件 (irAEs) 的潜力。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1737.001390.00- +
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5mg￥3775.003020.00- +
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10mg￥6625.005300.00- +
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50mg￥0.000.00- +
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100mg￥0.000.00- +
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- 货号: ajcx14038
- CAS: N/A
- 别名:
- 分子式: C144H227F3N40O50
- 分子量: 3375.63
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
NP-12 (TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. NP-12 (TFA) exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1]. PD-1 signaling pathway[1]
[1]. Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.
