- 首页
- HDAC (Histone deacetylases)
- PI3K/HDAC-IN-1
PI3K/HDAC-IN-1
PI3K/HDAC-IN-1 是一种有效的 (PI3K/HDAC) 双重抑制剂，高效抑制 PI3Kδ 和 HDAC1 的 IC50 值分别为 8.1 nM 和 1.4 nM。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
100mg￥0.000.00- +
-
250mg￥0.000.00- +
-
500mg￥0.000.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajcx14082
- CAS: 2361418-52-0
- 别名:
- 分子式: C22H25FN4O4
- 分子量: 428.46
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1]. PI3Kα|42 nM (IC50)|PI3Kβ|101 nM (IC50)|PI3Kγ|67 nM (IC50)|PI3Kδ|8.1 nM (IC50)|HDAC1|1.4 nM (IC50)|HDAC2|3.0 nM (IC50)|HDAC6|6.6 nM (IC50)|HDAC8|18 nM (IC50)
[1]. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29.
