PROTAC Linker 27 是一种 PROTAC 连接桥，属于 alkyl chain类。PROTAC Linker 27 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
货号:ajcx14094
CAS:N/A
分子式:C7H14N4O
分子量：170.21
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货
Background:
PROTAC Linker 27 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 27 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Alkyl-Chain
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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